POLE · AlphaFold Predicted Structure

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POLE

DNA Polymerase ε · AlphaFold Predicted Structure

UniProt Q07864

2,286 AA

AlphaFold v4

predicted

Representation

Color mode

Functional domains N → C

N-terminal domain

res. 1–280

NTD

3′→5′ Exonuclease

res. 268–471

EXO

Palm subdomain

res. 472–699

PALM

Processivity (P) domain

res. 700–760

P-DOM

Fingers subdomain

res. 761–1020

FNG

Thumb subdomain

res. 1021–1190

THM

Inactive Pol module

res. 1191–1900

INACT

C-terminal domain

res. 1901–2286

CTD

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c.138del Frameshift

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AlphaFold · predicted

AF-Q07864 · full-length 2,286 AA

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AlphaFold v4 · UniProt Q07864

cartoon pLDDT coloring

AlphaFold model

UniProt accession

Q07864 (DPOE1_HUMAN)

AlphaFold version

v4 (AlphaFold2)

Residues

2,286 AA (full-length)

Coverage

Predicted full-length structure

Confidence metric

pLDDT (per-residue)

pLDDT confidence

 >90 Very high confidence
 70–90 Confident
 50–70 Low confidence
 <50 Very low / disordered

pLDDT (predicted Local Distance Difference Test) is a per-residue confidence metric ranging from 0–100. Regions with pLDDT <50 are likely disordered or poorly predicted. Regions >90 are expected to be modeled with high accuracy.

Structure details

This viewer displays the AlphaFold predicted structure for the full-length POLE catalytic subunit (2,286 residues). Unlike experimental PDB structures which capture partial complexes, this model covers the entire polypeptide chain including regions not resolved in cryo-EM.

The default pLDDT coloring highlights regions of high vs. low prediction confidence. Structured catalytic domains (exonuclease, polymerase) typically show high confidence (>90), while flexible loops and disordered termini may show lower scores.

Model note

This is a computational prediction, not an experimentally determined structure. AlphaFold predictions should be interpreted alongside experimental data. For atomic-coordinate analysis from cryo-EM, use the Mol* Coordinate Viewer (PDB 9F6D).

References

        Jumper et al., Nature 596:583 (2021)

        Varadi et al., NAR 50:D439 (2022)

        Roske & Yeeles, NSMB 31:1921 (2024)